Squamous cell carcinoma - Carcinom Cu Celule Scuamoase
☆ În rezultatele Stiftung Warentest din Germania din 2022, satisfacția consumatorilor față de ModelDerm a fost doar puțin mai mică decât în cazul consultațiilor plătite de telemedicină.
Squamous cell carcinoma well differentiated ― Se observă o cheratoză actinică adiacentă.
References
Squamous cell carcinoma (SCC) este al doilea cel mai frecvent cancer de piele din Statele Unite, după basal cell carcinoma. De obicei, începe de la leziuni precanceroase numite actinic keratosis și se poate răspândi în alte părți ale corpului. Cauza principală este expunerea la radiațiile ultraviolete (UV) de la soare, care se acumulează în timp. Tratamentul implică de obicei îndepărtarea chirurgicală, în special pentru SCC pe cap și gât. Radioterapia este o opțiune pentru pacienții în vârstă sau pentru cei care nu se pot opera. Imunosupresia crește riscul de SCC. Deși rar, SCC se poate răspândi, în special la pacienții cu sistem imunitar slăbit. Controalele regulate și protecția solară sunt importante pentru cei cu SCC.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Cutaneous squamous cell carcinoma (CSCC) este al doilea cel mai frecvent cancer la oameni, iar numărul său este în creștere. Deși CSCC prezintă de obicei un comportament clinic benign, se poate răspândi atât local, cât și în alte părți ale corpului. Oamenii de știință au identificat căi specifice implicate în dezvoltarea CSCC, care conduc la noi tratamente. Numărul mare de mutații și riscul crescut la pacienții imunodeprimați au determinat dezvoltarea imunoterapiei. Această recenzie analizează rădăcinile genetice ale CSCC și cele mai recente tratamente care vizează molecule specifice și sistemul imunitar.
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
○ Diagnostic și tratament
#Dermoscopy
#Skin biopsy